Premium
T 2 measurement and quantification of cerebral white and gray matter aspartate concentrations in vivo at 3T: a MEGA‐PRESS study
Author(s) -
Menshchikov Petr,
Manzhurtsev Andrei,
Ublinskiy Maxim,
Akhadov Tolib,
Semenova Natalia
Publication year - 2019
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27700
Subject(s) - white matter , nuclear magnetic resonance , in vivo , chemistry , mega , nuclear medicine , magnetic resonance imaging , physics , medicine , biology , genetics , radiology , astronomy
Purpose To measure the transverse relaxation rate (T 2 ) of aspartate (Asp) from Asp‐edited MEGA‐PRESS spectra and use the measured T 2 values to estimate the Asp concentrations in gray matter (GM)‐ and white matter (WM)‐dominant brain regions. Methods Since Asp‐edited MEGA‐PRESS spectra contain non‐overlapped Asp signals, TE‐dependence arising from J‐evolution can be considered using phantom MEGA‐PRESS spectra acquired with the same parameters as in vivo spectra. Four TE values (90, 115, 140, and 150 ms) were selected from numeric analyses for effective detection of the edited Asp multiplet at ~2.71 ppm. The T 2 relaxation time was measured in the anterior cingulate cortex (ACC) of 16 healthy volunteers. Absolute cerebral Asp concentrations were measured with Asp‐edited MEGA‐PRESS in the ACC and left centrum semiovale (CS) of 44 healthy volunteers at TEs of 90, 115, 140, and 150 ms. Results The in vivo and phantom T 2 values of the edited Asp signals were 165 ± 37 ms and 313 ± 27 ms, respectively. The cortical GM concentration quantified was significantly greater than the WM concentration (2.80 ± 0.31 mM vs. 1.01 ± 0.18 mM). Conclusion MEGA‐PRESS is the most common editing method used for low‐concentration metabolites detection. Estimation of the absolute Asp concentrations has potential in many research applications, such as studying the processes underlying the reduction of N‐acetyl aspartate as well as studying mitochondrial diseases etc. The T 2 measurement method described has been successfully applied for edited Asp signals. This method can also be used for other strongly J‐coupled signals.