z-logo
Premium
Aortic 4D flow MRI in 2 minutes using compressed sensing, respiratory controlled adaptive k‐space reordering, and inline reconstruction
Author(s) -
Ma Liliana E.,
Markl Michael,
Chow Kelvin,
Huh Hyungkyu,
Forman Christoph,
Vali Alireza,
Greiser Andreas,
Carr James,
Schnell Susanne,
Barker Alex J.,
Jin Ning
Publication year - 2019
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27684
Subject(s) - pulsatile flow , nuclear medicine , voxel , imaging phantom , compressed sensing , magnetic resonance imaging , thoracic aorta , aorta , medicine , biomedical engineering , scanner , nuclear magnetic resonance , mathematics , radiology , physics , cardiology , computer science , algorithm , artificial intelligence
Purpose To evaluate the accuracy and feasibility of a free‐breathing 4D flow technique using compressed sensing (CS), where 4D flow imaging of the thoracic aorta is performed in 2 min with inline image reconstruction on the MRI scanner in less than 5 min. Methods The 10 in vitro 4D flow MRI scans were performed with different acceleration rates on a pulsatile flow phantom (9 CS acceleration factors [R = 5.4–14.1], 1 generalized autocalibrating partially parallel acquisition [GRAPPA] R = 2). Based on in vitro results, CS‐accelerated 4D flow of the thoracic aorta was acquired in 20 healthy volunteers (38.3 ± 15.2 years old) and 11 patients with aortic disease (61.3 ± 15.1 years) with R = 7.7. A conventional 4D flow scan was acquired with matched spatial coverage and temporal resolution. Results CS depicted similar hemodynamics to conventional 4D flow in vitro, and in vivo, with >70% reduction in scan time (volunteers: 1:52 ± 0:25 versus 7:25 ± 2:35 min). Net flow values were within 3.5% in healthy volunteers, and voxel‐by‐voxel comparison demonstrated good agreement. CS significantly underestimated peak velocities (v max ) and peak flow (Q max ) in both volunteers and patients ( volunteers : v max , −16.2% to −9.4%, Q max : −11.6% to −2.9%, patients : v max , −11.2% to −4.0%; Q max , −10.2% to −5.8%). Conclusion Aortic 4D flow with CS is feasible in a two minute scan with less than 5 min for inline reconstruction. While net flow agreement was excellent, CS with R = 7.7 produced underestimation of Q max and v max ; however, these were generally within 13% of conventional 4D flow‐derived values. This approach allows 4D flow to be feasible in clinical practice for comprehensive assessment of hemodynamics.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here