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Efficient shear wave elastography using transient acoustic radiation force excitations and MR displacement encoding
Author(s) -
Hofstetter Lorne W.,
Odéen Henrik,
Bolster Bradley D.,
Mueller Alexander,
Christensen Douglas A.,
Payne Allison,
Parker Dennis L.
Publication year - 2019
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27647
Subject(s) - acoustic radiation force , imaging phantom , elastography , wavefront , physics , acoustics , shear waves , transducer , pixel , optics , shear (geology) , ultrasound , biomedical engineering , materials science , medicine , composite material
Purpose To present a novel MR shear wave elastography (MR‐SWE) method that efficiently measures the speed of propagating wave packets generated using acoustic radiation force (ARF) impulses. Methods ARF impulses from a focused ultrasound (FUS) transducer were applied sequentially to a preselected set of positions and motion encoded MRI was used to acquire volumetric images of the propagating shear wavefront emanating from each point. The wavefront position at multiple propagation times was encoded in the MR phase image using a train of motion encoding gradient lobes. Generating a transient propagating wavefront at multiple spatial positions and sampling each at multiple time‐points allowed for shear wave speed maps to be efficiently created. MR‐SWE was evaluated in tissue mimicking phantoms and ex vivo bovine liver tissue before and after ablation. Results MR‐SWE maps, covering an in‐plane area of ~5 × 5 cm, were acquired in 12 s for a single slice and 144 s for a volumetric scan. MR‐SWE detected inclusions of differing stiffness in a phantom experiment. In bovine liver, mean shear wave speed significantly increased from 1.65 ± 0.18 m/s in normal to 2.52 ± 0.18 m/s in ablated region ( n = 581 pixels; P ‐value < 0.001). Conclusion MR‐SWE is an elastography technique that enables precise targeting and excitation of the desired tissue of interest. MR‐SWE may be particularly well suited for treatment planning and endpoint assessment of MR‐guided FUS procedures because the same device used for therapy can be used as an excitation source for tissue stiffness quantification.