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Functional lung imaging with transient spoiled gradient echo
Author(s) -
Bauman Grzegorz,
Pusterla Orso,
Bieri Oliver
Publication year - 2019
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27535
Subject(s) - lung , gradient echo , perfusion , nuclear magnetic resonance , biomedical engineering , nuclear medicine , magnetic resonance imaging , materials science , medicine , radiology , physics
Purpose To introduce an alternative framework for perfusion and ventilation lung imaging at 3 T using transient spoiled gradient echo (tSPGR) acquisitions. Methods Sets of coronal 2D time‐resolved lung image series were acquired in 5 healthy volunteers using tSPGR and compared with contemporary SPGR and ultrafast balanced SSFP (uf‐bSSFP) implementations at 1.5 T and 3 T. Sequence parameters and view ordering were optimized for tSPGR to yield maximum signal intensity in the lung tissue. Signal‐to‐noise ratio and contrast‐to‐noise ratio analyses were performed in all acquired tSPGR, SPGR, and uf‐bSSFP data sets. Matrix pencil decomposition was applied to generate functional parameter maps, including fractional ventilation, relative perfusion, and blood arrival time. Results For the lung, the signal intensity of tSPGR imaging was maximal for minimal TR and TE settings of 0.99 ms and 0.43 ms, respectively. Moreover, low RF spoiling increments in combination with a centric view ordering resulted in a further signal‐to‐noise ratio increase of about 30% to 40%. The average signal‐to‐noise ratio in the lung parenchyma was 73.3 for uf‐bSSFP, 38.1 for tSPGR, 20.7 for SPGR at 1.5 T, and 31.2 for uf‐bSSFP, 35.6 for tSPGR, and 21.3 for SPGR at 3 T. The average ventilation and perfusion contrast‐to‐noise ratio was 33.2 and 36.2 for uf‐bSSFP, 15.4 and 12.5 for tSPGR, 13.5 and 4.1 for SPGR at 1.5 T, and 16.5 and 11.3 for uf‐bSSFP, 29.7 and 50.8 for tSPGR, and 22.4 and 16.5 for SPGR at 3 T, respectively. Conclusion At 3 T, application of balanced SSFP is limited, so tSPGR offers an alternative framework for successful lung function assessment using matrix pencil MRI.