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In vivo hyperpolarization transfer in a clinical MRI scanner
Author(s) -
von Morze Cornelius,
Reed Galen D.,
Larson Peder E.,
Mammoli Daniele,
Chen Albert P.,
Tropp James,
Criekinge Mark,
Ohliger Michael A.,
Kurhanewicz John,
Vigneron Daniel B.,
Merritt Matthew E.
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27154
Subject(s) - hyperpolarization (physics) , in vivo , scanner , chemistry , imaging phantom , nuclear magnetic resonance , pulse sequence , nuclear medicine , nuclear magnetic resonance spectroscopy , medicine , physics , optics , biology , microbiology and biotechnology
Purpose The purpose of this study was to investigate the feasibility of in vivo 13 C‐> 1 H hyperpolarization transfer, which has significant potential advantages for detecting the distribution and metabolism of hyperpolarized 13 C probes in a clinical MRI scanner. Methods A standalone pulsed 13 C RF transmit channel was developed for operation in conjunction with the standard 1 H channel of a clinical 3T MRI scanner. Pulse sequences for 13 C power calibration and polarization transfer were programmed on the external hardware and integrated with a customized water‐suppressed 1 H MRS acquisition running in parallel on the scanner. The newly developed RF system was tested in both phantom and in vivo polarization transfer experiments in 1 J CH ‐coupled systems: phantom experiments in thermally polarized and hyperpolarized [2‐ 13 C]glycerol, and 1 H detection of [2‐ 13 C]lactate generated from hyperpolarized [2‐ 13 C]pyruvate in rat liver in vivo. Results Operation of the custom pulsed 13 C RF channel resulted in effective 13 C‐> 1 H hyperpolarization transfer, as confirmed by the characteristic antiphase appearance of 1 H‐detected, 1 J CH ‐coupled doublets. In conjunction with a pulse sequence providing 190‐fold water suppression in vivo, 1 H detection of hyperpolarized [2‐ 13 C]lactate generated in vivo was achieved in a rat liver slice. Conclusion The results show clear feasibility for effective 13 C‐> 1 H hyperpolarization transfer in a clinical MRI scanner with customized heteronuclear RF system.