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Simultaneous multislice triple‐echo steady‐state ( SMS‐TESS ) T 1 , T 2 , PD, and off‐resonance mapping in the human brain
Author(s) -
Heule Rahel,
Celicanin Zarko,
Kozerke Sebastian,
Bieri Oliver
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27126
Subject(s) - multislice , nuclear magnetic resonance , physics , echo (communications protocol) , resonance (particle physics) , relaxation (psychology) , nuclear medicine , analytical chemistry (journal) , chemistry , computer science , atomic physics , medicine , chromatography , computer network
Purpose To investigate the ability of simultaneous multislice triple‐echo steady‐state (SMS‐TESS) imaging to provide quantitative maps of multiple tissue parameters, i.e., longitudinal and transverse relaxation times (T 1 and T 2 ), proton density (PD), and off‐resonance (ΔB 0 ), in the human brain at 3T from a single scan. Methods TESS acquisitions were performed in 2D mode to reduce motion sensitivity and accelerated by an SMS excitation scheme (CAIPIRINHA) with SENSE reconstruction. SMS‐acceleration factors (R) of 2 and 4 were evaluated. The in vitro and in vivo validation process included standard reference scans to analyze the accuracy of T 1 , T 2 , and ΔB 0 estimates, as well as single‐slice TESS measurements. Results For R = 2, the quantification of T 1 , T 2 , PD, and ΔB 0 was overall reliable with marginal noise enhancement. T 1 and T 2 values were in good agreement with the reference measurements and single‐slice TESS. For R = 4, the agreement of ΔB 0 with the standard reference was excellent and the determination of T 1 , T 2 , and PD was reproducible; however, increased variations in T 1 and T 2 values with respect to single‐slice TESS were observed. Conclusion SMS‐TESS has shown potential to offer rapid simultaneous T 1 , T 2 , PD, and ΔB 0 mapping of human brain tissues.