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Human umbilical cord blood relaxation times and susceptibility at 3 T
Author(s) -
Portnoy Sharon,
Milligan Natasha,
Seed Mike,
Sled John G.,
Macgowan Christopher K.
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26978
Subject(s) - relaxometry , hematocrit , cord blood , umbilical cord , venous blood , chemistry , cord , magnetic resonance imaging , nuclear magnetic resonance , medicine , anatomy , surgery , physics , radiology , spin echo
Purpose To characterize the magnetic susceptibility and relaxation times (T 1 and T 2 ) of fetal blood at 3 T as a function of the hematocrit (Hct) and oxygen saturation (sO 2 ). Methods Susceptibility and relaxometry measurements were performed on cord blood specimens ( N = 90, derived from six caesarean deliveries) with a range of hematocrits and oxygen saturations (0.09 < Hct < 0.82, 7 < sO 2 < 100%). To obtain simple, analytic relationships between MRI properties and blood properties, data were fit to established two‐compartment (plasma and erythrocytes) models. Results Two‐compartment models effectively described the cord blood data. The root‐mean‐squared deviation between the model and the data was 6.3, 10.3, and 1.3% for fits to T 1 , T 2 , and susceptibility measurements. Relaxometry data and estimated T 1 and T 2 model parameters were generally consistent with those reported in cord blood at 1.5 T and comparable to published values for adult blood. Notably, the measured value of Δχ deo , the susceptibility difference between fully oxygenated (sO 2 = 100%) and deoxygenated (sO 2 = 0) cord blood was approximately 20% lower than the established adult blood value (Δχ deo,cord = 2.64 ppm, Δχ deo,adult = 3.4 ppm). Conclusions The described models and associated parameter values can be used to inform acquisition parameters, and interpret fetal/neonatal blood susceptibility measurements and relaxometry data acquired at 3 T with respect to hematocrit and sO 2 . Magn Reson Med 79:3194–3206, 2018. © 2017 International Society for Magnetic Resonance in Medicine.