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Respiratory variation in left ventricular cardiac function with 3 D double golden‐angle whole‐heart cine imaging
Author(s) -
Holst Karen,
Ugander Martin,
Sigfridsson Andreas
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26942
Subject(s) - expiration , respiratory system , magnetic resonance imaging , nuclear medicine , cardiology , breathing , medicine , cardiac cycle , nuclear magnetic resonance , anatomy , physics , radiology
Purpose To develop a 3‐dimensional free‐breathing cardiovascular MR technique for quantifying the variation in left ventricular end‐diastolic volume (LVEDV) during the respiratory cycle. Methods A 3‐dimensional radial trajectory with double golden‐angle ordering was used for free‐running data acquisition during free breathing in healthy volunteers ( N = 8). A respiratory self‐gating signal was extracted from the center of k‐space, and data were retrospectively binned into eight respiratory phases in end‐diastole. Three‐dimensional image volumes with 2‐mm isotropic spatial resolution were reconstructed with conjugate‐gradient sensitivity encoding for acquisition durations of 4.5, 9, and 25 min. The LVEDV was manually segmented for each respiratory phase and acquisition duration. Results Respiratory‐induced variation expressed as minimum LVEDV (during mid‐inspiration) relative to maximum LVEDV (during mid‐expiration) was 5.9 ± 0.3% for 4.5 min, 5.3 ± 0.4% for 9 min ( P = 0.64 versus 4.5 min), and 5.0 ± 0.4% for 25 min ( P = 0.25 versus 4.5 min, and P = 1.00 versus 9 min). Conclusions The proposed technique enables high spatial‐resolution quantification of the respiratory variation in LVEDV during free breathing in under 5 min, and was found to be 5 to 6% for healthy volunteers. Magn Reson Med 79:2693–2701, 2018. © 2017 International Society for Magnetic Resonance in Medicine.