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Simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy ( SAHA ) for dynamic contrast‐enhanced MRI of liver
Author(s) -
Ning Jia,
Sun Yongliang,
Xie Sheng,
Zhang Bida,
Huang Feng,
Koken Peter,
Smink Jouke,
Yuan Chun,
Chen Huijun
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26915
Subject(s) - pharmacokinetics , dynamic contrast enhanced mri , contrast (vision) , in vivo , dynamic contrast , magnetic resonance imaging , cirrhosis , hepatocellular carcinoma , nuclear medicine , perfusion , computer science , chemistry , medicine , radiology , artificial intelligence , biology , microbiology and biotechnology
Purpose To propose a simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy (SAHA) method for liver dynamic contrast‐enhanced MRI. Methods The proposed SAHA simultaneously acquired high temporal‐resolution 2D images for vascular input function extraction using Cartesian sampling and 3D large‐coverage high spatial‐resolution liver dynamic contrast‐enhanced images using golden angle stack‐of‐stars acquisition in an interleaved way. Simulations were conducted to investigate the accuracy of SAHA in pharmacokinetic analysis. A healthy volunteer and three patients with cirrhosis or hepatocellular carcinoma were included in the study to investigate the feasibility of SAHA in vivo. Results Simulation studies showed that SAHA can provide closer results to the true values and lower root mean square error of estimated pharmacokinetic parameters in all of the tested scenarios. The in vivo scans of subjects provided fair image quality of both 2D images for arterial input function and portal venous input function and 3D whole liver images. The in vivo fitting results showed that the perfusion parameters of healthy liver were significantly different from those of cirrhotic liver and HCC. Conclusions The proposed SAHA can provide improved accuracy in pharmacokinetic modeling and is feasible in human liver dynamic contrast‐enhanced MRI, suggesting that SAHA is a potential tool for liver dynamic contrast‐enhanced MRI. Magn Reson Med 79:2629–2641, 2018. © 2017 International Society for Magnetic Resonance in Medicine.