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Whole brain inhomogeneous magnetization transfer (ihMT) imaging: Sensitivity enhancement within a steady‐state gradient echo sequence
Author(s) -
Mchinda Samira,
Varma Gopal,
Prevost Valentin H.,
Le Troter Arnaud,
Rapacchi Stanislas,
Guye Maxime,
Pelletier Jean,
Ranjeva JeanPhilippe,
Alsop David C.,
Duhamel Guillaume,
Girard Olivier M.
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26907
Subject(s) - nuclear magnetic resonance , imaging phantom , magnetization transfer , reproducibility , sensitivity (control systems) , physics , pulse sequence , signal (programming language) , magnetic resonance imaging , computer science , materials science , mathematics , optics , medicine , electronic engineering , statistics , radiology , programming language , engineering
Purpose To implement, characterize, and optimize an interleaved inhomogeneous magnetization transfer (ihMT) gradient echo sequence allowing for whole‐brain imaging within a clinically compatible scan time. Theory and Methods A general framework for ihMT modelling was developed based on the Provotorov theory of radiofrequency saturation, which accounts for the dipolar order underpinning the ihMT effect. Experimental studies and numerical simulations were performed to characterize and optimize the ihMT‐gradient echo dependency with sequence timings, saturation power, and offset frequency. The protocol was optimized in terms of maximum signal intensity and the reproducibility assessed for a nominal resolution of 1.5 mm isotropic. All experiments were performed on healthy volunteers at 1.5T. Results An important mechanism driving signal optimization and leading to strong ihMT signal enhancement that relies on the dynamics of radiofrequency energy deposition has been identified. By taking advantage of the delay allowed for readout between ihMT pulse bursts, it was possible to boost the ihMT signal by almost 2‐fold compared to previous implementation. Reproducibility of the optimal protocol was very good, with an intra‐individual error < 2%. Conclusion The proposed sensitivity‐boosted and time‐efficient steady‐state ihMT‐gradient echo sequence, implemented and optimized at 1.5T, allowed robust high‐resolution 3D ihMT imaging of the whole brain within a clinically compatible scan time. Magn Reson Med 79:2607–2619, 2018. © 2017 International Society for Magnetic Resonance in Medicine.