Premium
Regularly incremented phase encoding – MR fingerprinting (RIPE‐MRF) for enhanced motion artifact suppression in preclinical cartesian MR fingerprinting
Author(s) -
Anderson Christian E.,
Wang Charlie Y.,
Gu Yuning,
Darrah Rebecca,
Griswold Mark A.,
Yu Xin,
Flask Chris A.
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26865
Subject(s) - artifact (error) , magnetic resonance imaging , imaging phantom , standard deviation , nuclear medicine , scanner , artificial intelligence , nuclear magnetic resonance , biomedical engineering , computer science , pattern recognition (psychology) , physics , mathematics , medicine , radiology , statistics
Purpose The regularly incremented phase encoding–magnetic resonance fingerprinting (RIPE‐MRF) method is introduced to limit the sensitivity of preclinical MRF assessments to pulsatile and respiratory motion artifacts. Methods As compared to previously reported standard Cartesian–MRF methods (SC‐MRF), the proposed RIPE‐MRF method uses a modified Cartesian trajectory that varies the acquired phase‐encoding line within each dynamic MRF dataset. Phantoms and mice were scanned without gating or triggering on a 7T preclinical MRI scanner using the RIPE‐MRF and SC‐MRF methods. In vitro phantom longitudinal relaxation time (T 1 ) and transverse relaxation time (T 2 ) measurements, as well as in vivo liver assessments of artifact‐to‐noise ratio (ANR) and MRF‐based T 1 and T 2 mean and standard deviation, were compared between the two methods (n = 5). Results RIPE‐MRF showed significant ANR reductions in regions of pulsatility ( P < 0.005) and respiratory motion ( P < 0.0005). RIPE‐MRF also exhibited improved precision in T 1 and T 2 measurements in comparison to the SC‐MRF method ( P < 0.05). The RIPE‐MRF and SC‐MRF methods displayed similar mean T 1 and T 2 estimates (difference in mean values < 10%). Conclusion These results show that the RIPE‐MRF method can provide effective motion artifact suppression with minimal impact on T 1 and T 2 accuracy for in vivo small animal MRI studies. Magn Reson Med 79:2176–2182, 2018. © 2017 International Society for Magnetic Resonance in Medicine.