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Transverse relaxation time constants of the five major metabolites in human brain measured in vivo using LASER and PRESS at 3 T
Author(s) -
Deelchand Dinesh K.,
Auerbach Edward J.,
Kobayashi Naoharu,
Marjańska Małgorzata
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26826
Subject(s) - nuclear magnetic resonance , creatine , chemistry , relaxation (psychology) , laser , choline , glutamate receptor , in vivo , raman spectroscopy , human brain , time constant , analytical chemistry (journal) , physics , biochemistry , biology , optics , chromatography , neuroscience , receptor , microbiology and biotechnology , electrical engineering , engineering
Purpose The goal of this study was to measure and compare the apparent transverse relaxation time constants (T 2 ) of five intracellular metabolites using localization by adiabatic selective refocusing (LASER) and point‐resolved spectroscopy (PRESS) sequences in the human brain at 3 T. Methods Five healthy subjects were studied at 3 T. 1 H spectra from the prefrontal cortex were acquired at six different echo times using LASER and PRESS sequences. Postprocessed data were analyzed with LCModel, and the resulting amplitudes were fitted using a mono‐exponential decay function to determine the T 2 of metabolites. Results Twenty‐one percent higher apparent T 2 values for the singlet resonances of N ‐acetyl aspartate, total creatine, and total choline were measured with LASER as compared with PRESS, whereas comparable apparent T 2 values were measured for strongly coupled metabolites, glutamate, and myo ‐inositol, with both sequences. Conclusions Reliable T 2 measurements were obtained with both sequences for the five major intracellular metabolites. The LASER sequence appears to be more efficient in suppressing the diffusion component for singlets (having nonexchangeable protons) compared to J ‐coupled metabolites. Magn Reson Med 79:1260–1265, 2018. © 2017 International Society for Magnetic Resonance in Medicine.