Premium
Cardiac quantitative susceptibility mapping (QSM) for heart chamber oxygenation
Author(s) -
Wen Yan,
Nguyen Thanh D.,
Liu Zhe,
Spincemaille Pascal,
Zhou Dong,
Dimov Alexey,
Kee Youngwook,
Deh Kofi,
Kim Jiwon,
Weinsaft Jonathan W.,
Wang Yi
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26808
Subject(s) - quantitative susceptibility mapping , ventricle , medicine , magnetic resonance imaging , blood oxygenation , cardiology , biomedical engineering , nuclear medicine , radiology , functional magnetic resonance imaging
Purpose To demonstrate the feasibility of in vivo quantitative susceptibility mapping (QSM) in cardiac MRI and to show that mixed‐venous oxygen saturation (SvO 2 ) can be measured non‐invasively using QSM. Methods Electrocardiographic‐gated multi‐echo 2D gradient echo data were collected at 1.5 T from 14 healthy volunteers during successive breath‐holds. Phase wraps and fat chemical shift were removed using a graph‐cut‐based phase analysis and IDEAL in an iterative approach. The large susceptibility range from air in the lungs to blood in the heart was addressed by using the preconditioning approach in the dipole field inversion. SvO 2 was calculated based on the difference in blood susceptibility between the right ventricle (RV) and left ventricle (LV). Cardiac QSM quality was assessed by two independent readers. Results Nine out of fourteen volunteers (64%) yielded interpretable cardiac QSM. QSM maps showed strong differential contrast between RV and LV blood with RV blood having higher susceptibility values (291.5 ± 32.4 ppb), which correspond to 78.3 ± 2.3% SvO 2 . Conclusion In vivo cardiac QSM is feasible and can be used to measure SvO 2 , but improvements in data acquisition are needed. Magn Reson Med 79:1545–1552, 2018. © 2017 International Society for Magnetic Resonance in Medicine.