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Quantitative magnetization transfer ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence
Author(s) -
Ma YaJun,
Chang Eric Y.,
Carl Michael,
Du Jiang
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26716
Subject(s) - magnetization transfer , pulse sequence , cadaveric spasm , nuclear magnetic resonance , magnetic resonance imaging , pulse (music) , relaxation (psychology) , materials science , chemistry , physics , optics , biology , medicine , biochemistry , neuroscience , detector , radiology
Purpose To accelerate the quantitative ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence with magnetization transfer (3D UTE‐Cones‐MT) and signal modeling. Theory and Methods A 3D UTE‐Cones‐MT acquisition scheme with multispoke per MT preparation and a modified rectangular pulse (RP) approximation was developed for two‐pool MT modeling of macromolecular and water components including their relative fractions, relaxation times and exchange rates. Numerical simulation and cadaveric specimens, including human Achilles tendon and bovine cortical bone, were investigated using a clinical 3T scanner. Results Numerical simulation showed that the modified RP model provided accurate estimation of MT parameters when multispokes were acquired per MT preparation. For the experiment with the Achilles tendon and cortical bone samples, the macromolecular fractions were 20.4 ± 2.0% and 59.4 ± 5.3%, respectively. Conclusion The 3D multispoke UTE‐Cones‐MT sequence can be used for fast volumetric assessment of macromolecular and water components in short T 2 tissues. Magn Reson Med 79:692–700, 2018. © 2017 International Society for Magnetic Resonance in Medicine.