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MR fingerprinting for rapid quantification of myocardial T 1 , T 2 , and proton spin density
Author(s) -
Hamilton Jesse I.,
Jiang Yun,
Chen Yong,
Ma Dan,
Lo WeiChing,
Griswold Mark,
Seiberlich Nicole
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26668
Subject(s) - imaging phantom , dephasing , flip angle , nuclear magnetic resonance , pulse sequence , physics , magnetic resonance imaging , relaxometry , spin echo , nuclear medicine , pattern recognition (psychology) , computer science , artificial intelligence , medicine , radiology , optics , quantum mechanics
Purpose To introduce a two‐dimensional MR fingerprinting (MRF) technique for quantification of T 1 , T 2 , and M 0 in myocardium. Methods An electrocardiograph‐triggered MRF method is introduced for mapping myocardial T 1 , T 2 , and M 0 during a single breath‐hold in as short as four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery times, and T 2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate. Aspects of the sequence design were explored in simulations, and the accuracy and precision of cardiac MRF were assessed in a phantom study. In vivo imaging was performed at 3 Tesla in 11 volunteers to generate native parametric maps. Results T 1 and T 2 measurements from the proposed cardiac MRF sequence correlated well with standard spin echo measurements in the phantom study (R 2 > 0.99). A Bland‐Altman analysis revealed good agreement for myocardial T 1 measurements between MRF and MOLLI (bias 1 ms, 95% limits of agreement −72 to 72 ms) and T 2 measurements between MRF and T 2 ‐prepared balanced steady‐state free precession (bias, −2.6 ms; 95% limits of agreement, −8.5 to 3.3 ms). Conclusion MRF can provide quantitative single slice T 1 , T 2 , and M 0 maps in the heart within a single breath‐hold. Magn Reson Med 77:1446–1458, 2017. © 2016 International Society for Magnetic Resonance in Medicine