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Diffusion‐relaxation correlation spectroscopic imaging: A multidimensional approach for probing microstructure
Author(s) -
Kim Daeun,
Doyle Eamon K.,
Wisnowski Jessica L.,
Kim Joong Hee,
Haldar Justin P.
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26629
Subject(s) - voxel , relaxation (psychology) , diffusion mri , diffusion , magnetic resonance imaging , imaging phantom , nuclear magnetic resonance , diffusion imaging , correlation , computer science , statistical physics , biological system , biomedical engineering , physics , artificial intelligence , optics , mathematics , neuroscience , radiology , medicine , geometry , thermodynamics , biology
Purpose To propose and evaluate a novel multidimensional approach for imaging subvoxel tissue compartments called Diffusion‐Relaxation Correlation Spectroscopic Imaging. Theory and Methods Multiexponential modeling of MR diffusion or relaxation data is commonly used to infer the many different microscopic tissue compartments that contribute signal to macroscopic MR imaging voxels. However, multiexponential estimation is known to be difficult and ill‐posed. Observing that this ill‐posedness is theoretically reduced in higher dimensions, diffusion‐relaxation correlation spectroscopic imaging uses a novel multidimensional imaging experiment that jointly encodes diffusion and relaxation information, and then uses a novel constrained reconstruction technique to generate a multidimensional diffusion‐relaxation correlation spectrum for every voxel. The peaks of the multidimensional spectrum are expected to correspond to the distinct tissue microenvironments that are present within each macroscopic imaging voxel. Results Using numerical simulations, experiment data from a custom‐built phantom, and experiment data from a mouse model of traumatic spinal cord injury, diffusion‐relaxation correlation spectroscopic imaging is demonstrated to provide substantially better multicompartment resolving power compared to conventional diffusion‐ and relaxation‐based methods. Conclusion The diffusion‐relaxation correlation spectroscopic imaging approach provides powerful new capabilities for resolving the different components of multicompartment tissue models, and can be leveraged to significantly expand the insights provided by MRI in studies of tissue microstructure. Magn Reson Med 78:2236–2249, 2017. © 2017 International Society for Magnetic Resonance in Medicine.