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In vivo quantification of aortic stiffness using MR elastography in hypertensive porcine model
Author(s) -
Dong Huiming,
Mazumder Ria,
Illapani Venkata Sita Priyanka,
Mo Xiaokui,
White Richard D.,
Kolipaka Arunark
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26601
Subject(s) - magnetic resonance elastography , medicine , aorta , stiffness , magnetic resonance imaging , pulse pressure , cardiology , pulse wave velocity , nuclear medicine , radiology , elastography , blood pressure , ultrasound , materials science , composite material
Purpose Aortic stiffness plays an important role in evaluating and predicting the progression of systemic arterial hypertension (SAH). The aim of this study is to determine the stiffness of aortic wall using MR elastography (MRE) in a hypertensive porcine model and compare it against invasive aortic pressure measurements. Methods Renal wrapping surgery was performed on eight pigs to induce SAH. Aortic MRE was performed at baseline and 2 months postsurgery using a retrospectively pulse‐gated gradient‐echo MRE sequence on a 1.5 tesla scanner. Mechanical waves of 70 Hz were introduced into the aorta. Invasive central aortic pressure measurements were obtained prior to each scan to calculate mean arterial pressure (MAP). MRE data were analyzed to obtain effective aortic stiffness. Spearman's rank correlation analysis was performed to assess the relationship between MAP and MRE‐derived aortic stiffness. Results Significant increase in effective aortic stiffness was observed between baseline and 2 months postsurgery measurements (paired t test; P = 0.004). The average MAP, determined by pooling all animals, was 65.24 ± 9.42 mm Hg at baseline and 92.57 ± 11.80 mm Hg 2 months postsurgery with P < 0.0001. Moderate linear correlation was observed between MAP and effective aortic stiffness ( ρ = 0.52; P = 0.046). Conclusion This study demonstrated that, in a SAH porcine model, MRE‐derived aortic stiffness increased with increase in MAP. Magn Reson Med 78:2315–2321, 2017. © 2017 International Society for Magnetic Resonance in Medicine.