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Dual‐volume excitation and parallel reconstruction for J‐difference‐edited MR spectroscopy
Author(s) -
Oeltzschner Georg,
Puts Nicolaas A.J.,
Chan Kimberly L.,
Boer Vincent O.,
Barker Peter B.,
Edden Richard A.E.
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26536
Subject(s) - excitation , volume (thermodynamics) , nuclear magnetic resonance , spectroscopy , physics , nuclear medicine , materials science , medicine , quantum mechanics
Purpose To develop J‐difference editing with parallel reconstruction in accelerated multivoxel (PRIAM) for simultaneous measurement in two separate brain regions of γ‐aminobutyric acid (GABA) or glutathione. Methods PRIAM separates signals from two simultaneously excited voxels using receiver‐coil sensitivity profiles. PRIAM was implemented into Mescher‐Garwood (MEGA) edited experiments at 3 Tesla (T), and validated by acquiring dual‐voxel MEGA‐PRIAM (and compared with conventional single‐voxel MEGA‐PRESS) spectra from a GABA/glutathione phantom, and 11 healthy participants. Results MEGA‐PRIAM effectively separated phantom spectra with ∼3–4% between‐voxel contamination. GABA and glutathione measurements agreed well with those obtained using single‐voxel MEGA‐PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA‐ and glutathione‐edited spectra were successfully reconstructed with a mean in vivo g ‐factor of 1.025 (typical voxel‐center separation: 7–8 cm). MEGA‐PRIAM experiments showed higher signal‐to‐noise ratio than sequential single‐voxel experiments of the same total duration (mean improvement 1.38 ± 0.24). Conclusions Simultaneous acquisition of J‐difference‐edited GABA or glutathione spectra from two voxels is feasible at 3 T. MEGA‐PRIAM increases data acquisition rates compared with MEGA‐PRESS by a factor of 2. Magn Reson Med 77:16–22, 2017. © 2016 International Society for Magnetic Resonance in Medicine