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Detection of glucose in the human brain with 1 H MRS at 7 Tesla
Author(s) -
Kaiser Lana G.,
Hirokazu Kawaguchi,
Fukunaga Masaki,
B.Matson Gerald
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26456
Subject(s) - imaging phantom , nuclear magnetic resonance , in vivo , human brain , choline , chemistry , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , nuclear medicine , physics , medicine , neuroscience , biochemistry , biology , radiology , microbiology and biotechnology
Purpose A new method is proposed for noninvasive detection of glucose in vivo using proton MR spectroscopy at 7 Tesla. Theory and Methods The proposed method utilizes J‐difference editing to uncover the resonance of beta‐glucose (β‐glc) at 3.23 ppm, which is strongly overlapped with choline. Calculations using the density matrix formalism are used to maximize the signal‐to‐noise ratio of the β‐glc resonance at 3.23 ppm. The calculations are verified using phantom and in vivo data collected at 7 Tesla. Results The proposed method allows observation of the glucose signal at 3.23 ppm in the human brain spectrum. Additional co‐edited resonances of N‐acetylaspartylglutamatate and glutathione are also detected in the same experiment. Conclusion The proposed method does not require carbon ( 13 C)‐ labeled glucose injections and 13 C hardware; as such, it has a potential to provide valuable information on intrinsic glucose concentration in the human brain in vivo. Magn Reson Med 76:1653–1660, 2016. © 2016 International Society for Magnetic Resonance in Medicine