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Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks
Author(s) -
MüllerLutz Anja,
Cronenberg Tom,
Schleich Christoph,
Wickrath Frithjof,
Zaiss Moritz,
Boos Johannes,
Wittsack HansJörg
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26362
Subject(s) - chemistry , magnetization transfer , nuclear magnetic resonance , intervertebral disk , magnetic resonance imaging , lumbar , analytical chemistry (journal) , intervertebral disc , saturation (graph theory) , nuclear medicine , anatomy , physics , medicine , radiology , mathematics , chromatography , combinatorics
Purpose To investigate, if a train of spin‐lock pulses (chemical exchange saturation transfer with spin‐lock pulses = CESL) improves biochemical glycosaminoglycan imaging compared with conventional chemical exchange saturation transfer with Gaussian‐shaped pulses (CEST) in lumbar intervertebral discs. Methods T 2 , CEST, and CESL imaging was performed in lumbar intervertebral discs of 15 healthy volunteers at 3 Tesla. Mean and standard deviation of the asymmetric magnetization transfer ratio (MTR asym ), the asymmetric spin‐lock ratio (SLR asym ) and T 2 values were calculated for nucleus pulposus (NP) and annulus fibrosus (AF). Wilcoxon test was used to analyze differences between MTR asym and SLR asym . Pearson correlation was used to determine the relationship between MTR asym , SLR asym and T 2 . Results Data showed no significant difference between MTR asym and SLR asym (NP: P = 0.35; AF: P = 0.34). MTR asym and SLR asym values differed significantly between NP and AF (MTR asym : P = 0.014, SLR asym : P = 0.005). T 2 values correlated significantly with MTR asym (NP: ρ = 0.76, P < 0.001; AF: ρ = 0.60, P < 0.001) and SLR asym (NP: ρ = 0.73, P < 0.001; AF: ρ = 0.47, P < 0.001). Conclusion CESL does not improve the chemical exchange asymmetry effect compared with conventional CEST, but leads to comparable results. Magn Reson Med 78:280–284, 2017. © 2016 International Society for Magnetic Resonance in Medicine