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Accelerated chemical shift imaging of hyperpolarized 13 C metabolites
Author(s) -
Wang JianXiong,
Merritt Matthew E.,
Sherry A. Dean,
Malloy Craig R.
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26286
Subject(s) - compressed sensing , scanner , data acquisition , chemistry , dynamic imaging , nuclear magnetic resonance , computer science , physics , artificial intelligence , image processing , digital image processing , image (mathematics) , operating system
Purpose Chemical shift imaging (CSI) has long been considered the gold standard method for in vivo hyperpolarized 13 C metabolite imaging because of its high sensitivity. However, CSI requires a large number of excitations so it is desirable to reduce the number of RF excitations and the total acquisition time. Methods Centric phase encoding and three‐dimensional compressed sensing methods were adopted into a CSI acquisition to improve efficiency and reduce the number of excitations required for imaging hyperpolarized metabolites. The new method was implemented on a GE MR750W scanner for routine real time metabolic imaging experiments. Results Imaging results from phantoms and in vivo animals using hyperpolarized 13 C tracers demonstrate that when the entire CSI dataset is treated as a single object, compressed sensing can be satisfactorily applied to spectroscopic CSI. Centric k‐space trajectory data collection also greatly improves the acquisition efficiency. This combination of compressed sensing CSI and acquisition time reduction was used to perform a hyperpolarized 13 C dynamic study. Conclusion Compressed sensing can be satisfactorily applied to conventional CSI in hyperpolarized 13 C metabolite MR imaging to reduce the number of RF excitations and accelerate the imaging speed to take advantage of conventional CSI in providing high sensitivity and a large spectral bandwidth. Magn Reson Med 76:1033–1038, 2016. © 2016 Wiley Periodicals, Inc.