Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized  13 C, 15 N‐Urea | Zendy

Bertelsen Lotte B. | Zendy; Nielsen Per M. | Zendy; Qi Haiyun | Zendy; Nørlinger Thomas S. | Zendy; Zhang Xiaolu | Zendy; StødkildeJørgensen Hans | Zendy; Laustsen Christoffer | Zendy

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Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13 C, 15 N‐Urea

Author(s) -

Bertelsen Lotte B.,

Nielsen Per M.,

Qi Haiyun,

Nørlinger Thomas S.,

Zhang Xiaolu,

StødkildeJørgensen Hans,

Laustsen Christoffer

Publication year - 2017

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.26256

Subject(s) - urea , chemistry , renal function , diabetes mellitus , medicine , endocrinology , kidney , creatinine , nuclear magnetic resonance , biochemistry , physics

Purpose In the current study, we investigated hyperpolarized urea as a possible imaging biomarker of the renal function by means of the intrarenal osmolality gradient. Methods Hyperpolarized three‐dimensional balanced steady state 13 C MRI experiments alongside kidney function parameters and quantitative polymerase chain reaction measurements was performed on two groups of rats, a streptozotocin type 1 diabetic group and a healthy control group. Results A significant decline in intrarenal steepness of the urea gradient was found after 4 weeks of untreated insulinopenic diabetes in agreement with an increased urea transport transcription. Conclusion MRI and hyperpolarized [ 13 C, 15 N]urea can monitor the changes in the corticomedullary urea concentration gradients in diabetic and healthy control rats. Magn Reson Med 77:1650–1655, 2017. © 2016 International Society for Magnetic Resonance in Medicine

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