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Impact of tissue T 1 on perfusion measurement with arterial spin labeling
Author(s) -
Debacker Clément S.,
Daoust Alexia,
Köhler Sascha,
Voiron Jérôme,
Warnking Jan M.,
Barbier Emmanuel L.
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26255
Subject(s) - arterial spin labeling , perfusion , nuclear magnetic resonance , biomedical engineering , nuclear medicine , chemistry , medicine , physics , cardiology
Purpose Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T 1 on CBF quantification using ASL. Methods To locally modify T 1 , a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T 1 and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T. Results Mn reduced the tissue T 1 by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single‐compartment model, the use of a single tissue T 1 value yielded a mean relative ipsilateral (Mn‐injected) to contralateral (noninjected) CBF difference of −34% in cortex and −22% in striatum tissue. With a T 1 map, these values became −7% and +8%, respectively. Conclusion A low dose of Mn reduces the tissue T 1 without modifying CBF. Heterogeneous T 1 impacts the ASL estimate of CBF in a region‐dependent way. In animals, and when T 1 modifications exceed the accuracy with which the tissue T 1 can be determined, an estimate of tissue T 1 should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656–1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine