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High resolution spectroscopy and chemical shift imaging of hyperpolarized 129 Xe dissolved in the human brain in vivo at 1.5 tesla
Author(s) -
Rao Madhwesha,
Stewart Neil J.,
Norquay Graham,
Griffiths Paul D.,
Wild Jim M.
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26241
Subject(s) - chemistry , spectroscopy , radiofrequency coil , nuclear magnetic resonance , xenon , resolution (logic) , spectral line , isotopes of xenon , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , nmr spectra database , spectral resolution , magnetic resonance imaging , medicine , physics , organic chemistry , chromatography , quantum mechanics , astronomy , artificial intelligence , computer science , radiology
Purpose Upon inhalation, xenon diffuses into the bloodstream and is transported to the brain, where it dissolves in various compartments of the brain. Although up to five chemically distinct peaks have been previously observed in 129 Xe rat head spectra, to date only three peaks have been reported in the human head. This study demonstrates high resolution spectroscopy and chemical shift imaging (CSI) of 129 Xe dissolved in the human head at 1.5 Tesla. Methods A 129 Xe radiofrequency coil was built in‐house and 129 Xe gas was polarized using spin‐exchange optical pumping. Following the inhalation of 129 Xe gas, NMR spectroscopy was performed with spectral resolution of 0.033 ppm. Two‐dimensional CSI in all three anatomical planes was performed with spectral resolution of 2.1 ppm and voxel size 20 mm × 20 mm. Results Spectra of hyperpolarized 129 Xe dissolved in the human head showed five distinct peaks at 188 ppm, 192 ppm, 196 ppm, 200 ppm, and 217 ppm. Assignment of these peaks was consistent with earlier studies. Conclusion High resolution spectroscopy and CSI of hyperpolarized 129 Xe dissolved in the human head has been demonstrated. For the first time, five distinct NMR peaks have been observed in 129 Xe spectra from the human head in vivo. Magn Reson Med 75:2227–2234, 2016. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.