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Mitigation of partial volume effects in susceptibility‐based oxygenation measurements by joint utilization of magnitude and phase (JUMP)
Author(s) -
McDaniel Patrick,
Bilgic Berkin,
Fan Audrey P.,
Stout Jeffrey N.,
Adalsteinsson Elfar
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26227
Subject(s) - voxel , partial volume , jump , magnetic resonance imaging , oxygenation , nuclear magnetic resonance , volume (thermodynamics) , chemistry , materials science , nuclear medicine , physics , thermodynamics , radiology , medicine , quantum mechanics , anesthesia
Purpose Susceptibility‐based blood oxygenation measurements in small vessels of the brain derive from gradient echo (GRE) phase and can provide localized assessment of brain function and pathology. However, when vessel diameter becomes smaller than the acquisition voxel size, partial volume effects compromise these measurements. The purpose of this study was to develop a technique to improve the reliability of vessel oxygenation estimates in the presence of partial volume effects. Methods Intravoxel susceptibility variations are present when a vessel and parenchyma experience partial volume effects, modifying the voxel's GRE phase signal and attenuating the GRE magnitude signal. Using joint utilization of magnitude and phase (JUMP), both vessel susceptibility and voxel partial volume fraction can be estimated, providing measurements of venous oxygen saturation ( Y v ) in straight, nearly vertical vessels that have improved robustness to partial volume effects. Results JUMP was demonstrated by estimating vesselY vin numerical and in vivo experiments. Deviations from ground truth ofY vmeasurements in vessels tilted up to 30° fromB 0were reduced by over 50% when using JUMP compared with phase‐only techniques. Conclusion JUMP exploits both magnitude and phase data in GRE imaging to mitigate partial volume effects in estimation of vessel oxygenation. Magn Reson Med 77:1713–1727, 2017. © 2016 International Society for Magnetic Resonance in Medicine