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Blood oxygen‐level dependent functional assessment of cerebrovascular reactivity: Feasibility for intraoperative 3 Tesla MRI
Author(s) -
Fierstra Jorn,
Burkhardt JanKarl,
van Niftrik Christiaan Hendrik Bas,
Piccirelli Marco,
Pangalu Athina,
Kocian Roman,
Neidert Marian Christoph,
Valavanis Antonios,
Regli Luca,
Bozinov Oliver
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26135
Subject(s) - medicine , magnetic resonance imaging , blood oxygen level dependent , voxel , nuclear medicine , radiology , cerebral blood flow , cardiology
Purpose To assess the feasibility of functional blood oxygen‐level dependent (BOLD) MRI to evaluate intraoperative cerebrovascular reactivity (CVR) at 3 Tesla field strength. Methods Ten consecutive neurosurgical subjects scheduled for a clinical intraoperative MRI examination were enrolled in this study. In addition to the clinical protocol a BOLD sequence was implemented with three cycles of 44 s apnea to calculate CVR values on a voxel‐by‐voxel basis throughout the brain. The CVR range was then color‐coded and superimposed on an anatomical volume to create high spatial resolution CVR maps. Results Ten subjects (mean age 34.8 ± 13.4; 2 females) uneventfully underwent the intraoperative BOLD protocol, with no complications occurring. Whole‐brain CVR for all subjects was (mean ± SD) 0.69 ± 0.42, whereas CVR was markedly higher for tumor subjects as compared to vascular subjects, 0.81 ± 0.44 versus 0.33 ± 0.10, respectively. Furthermore, color‐coded functional maps could be robustly interpreted for a whole‐brain assessment of CVR. Conclusion We demonstrate that intraoperative BOLD MRI is feasible in creating functional maps to assess cerebrovascular reactivity throughout the brain in subjects undergoing a neurosurgical procedure. Magn Reson Med 77:806–813, 2017. © 2016 International Society for Magnetic Resonance in Medicine