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Simultaneous dynamic R 2 R 2 ' , and R 2 * measurement using periodic π pulse shifting multiecho asymmetric spin echo sequence moving estimation strategy: A feasibility study for lower extremity muscle
Author(s) -
Wang Chengyan,
Zhang Rui,
Zhang Xiaodong,
Wang He,
Zhao Kai,
Jin Lixin,
Zhang Jue,
Wang Xiaoying,
Fang Jing
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26126
Subject(s) - reproducibility , echo (communications protocol) , spin echo , pulse sequence , nuclear magnetic resonance , pulse (music) , imaging phantom , fast spin echo , magnetic resonance imaging , sequence (biology) , computer science , biomedical engineering , physics , mathematics , chemistry , medicine , optics , radiology , computer network , biochemistry , statistics , detector
Purpose The purpose of this study was to demonstrate the feasibility of simultaneous dynamic R 2 ,R 2 ' , andR 2 *measurement of lower extremity muscle by means of a new method in which the periodic π pulse shifting multiecho asymmetric spin echo (psMASE) sequence is adopted together with a moving estimation (ME) strategy. Theory and Methods The psMASE sequence is a modification of the multiecho asymmetric spin echo sequence determined by shifting the 180 ° refocusing pulse periodically. ME strategy is introduced to improve the temporal resolution of the simultaneous dynamic measurement of R 2 ,R 2 ' , andR 2 * . Reproducibility measurements and comparison with reference methods were conducted. Furthermore, this method was tested on 10 healthy volunteers with the dynamic imaging of lower extremity muscles during a cuff occlusion release paradigm. Results Both phantom and in vivo comparisons demonstrated that psMASE‐ME–based R 2 andR 2 *had good agreement with those calculated by multiecho spin echo and gradient echo sequences. Scan–rescan tests showed good reproducibility. Moreover, muscle R 2 ,R 2 ' , andR 2 *increased obviously from rest to cuff occlusion and decreased significantly after cuff release. Conclusion It is feasible to obtain high temporally resolved R 2 ,R 2 ' , andR 2 *simultaneously with the proposed psMASE‐ME method. Magn Reson Med 77:766–773, 2017. © 2016 International Society for Magnetic Resonance in Medicine