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Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐ 13 C]pyruvate and 13 C‐urea
Author(s) -
Lau Angus Z.,
Miller Jack J.,
Robson Matthew D.,
Tyler Damian J.
Publication year - 2017
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26106
Subject(s) - urea , metabolism , chemistry , perfusion , radiochemistry , biochemistry , medicine
Purpose To demonstrate the feasibility of imaging a bolus of co‐polarized [1‐ 13 C]pyruvate and 13 C‐urea to simultaneously assess both metabolism and perfusion in the rodent heart. Methods Copolarized [1‐ 13 C]pyruvate and 13 C‐urea was imaged using a multi‐echo, flow‐sensitized spiral pulse sequence. Healthy rats were scanned in a two‐factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress‐induced hyperemia). Results Alterations in metabolism were detected by changes in pyruvate metabolism into 13 C‐bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals. Conclusion The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized 13 C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151–158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine