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Localized one‐dimensional single voxel magnetic resonance spectroscopy without J coupling modulations
Author(s) -
Lin Yanqin,
Lin Liangjie,
Wei Zhiliang,
Zhong Jianhui,
Chen Zhong
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26066
Subject(s) - voxel , pulse sequence , nuclear magnetic resonance , physics , coupling (piping) , imaging phantom , j coupling , phase (matter) , amplitude , magnetic resonance imaging , spin echo , pulse (music) , nuclear magnetic resonance spectroscopy , spectral line , spectroscopy , signal (programming language) , sequence (biology) , relaxation (psychology) , resonance (particle physics) , chemistry , optics , atomic physics , materials science , computer science , artificial intelligence , detector , psychology , biochemistry , quantum mechanics , metallurgy , radiology , programming language , medicine , astronomy , social psychology
Purpose To acquire single voxel localized one‐dimensional 1 H magnetic resonance spectroscopy (MRS) without J coupling modulations, free from amplitude and phase distortions. Methods A pulse sequence, named PRESSIR, is developed for volume localized MRS without J modulations at arbitrary echo time (TE). The J coupling evolution is suppressed by the J ‐refocused module that uses a 90° pulse at the midpoint of a double spin echo. Results The localization performance of the PRESSIR sequence was tested with a two‐compartment phantom. The proposed sequence shows similar voxel localization accuracy as PRESS. Both PRESSIR and PRESS sequences were performed on MRS brain phantom and pig brain tissue. PRESS spectra suffer from amplitude and phase distortions due to J modulations, especially under moderate and long TEs, while PRESSIR spectra are almost free from distortions. Conclusion The PRESSIR sequence proposed herein enables the acquisition of single voxel in‐phase MRS within a single scan. It allows an enhanced signal intensity of J coupling metabolites and reducing undesired broad resonances with short T2s while suppressing J modulations. Moreover, it provides an approach for direct measurement of nonoverlapping J coupling peaks and of transverse relaxation times T2s. Magn Reson Med 76:1661–1667, 2016. © 2015 International Society for Magnetic Resonance in Medicine