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Joint myocardial T 1 and T 2 mapping using a combination of saturation recovery and T 2 ‐preparation
Author(s) -
Akçakaya Mehmet,
Weingärtner Sebastian,
Basha Tamer A.,
Roujol Sébastien,
Bellm Steven,
Nezafat Reza
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25975
Subject(s) - imaging phantom , pulse sequence , heartbeat , joint (building) , computer science , sequence (biology) , pattern recognition (psychology) , artificial intelligence , physics , nuclear magnetic resonance , mathematics , optics , chemistry , architectural engineering , biochemistry , engineering , computer security
Purpose To develop a heart‐rate independent breath‐held joint T 1 –T 2 mapping sequence for accurate simultaneous estimation of coregistered myocardial T 1 and T 2 maps. Methods A novel preparation scheme combining both a saturation pulse and T 2 ‐preparation in a single R–R interval is introduced. The time between these two pulses, as well as the duration of the T 2 ‐preparation is varied in each heartbeat, acquiring images with different T 1 and T 2 weightings, and no magnetization dependence on previous images. Inherently coregistered T 1 and T 2 maps are calculated from these images. Phantom imaging is performed to compare the proposed maps with spin echo references. In vivo imaging is performed in ten subjects, comparing the accuracy and precision of the proposed technique to existing myocardial T 1 and T 2 mapping sequences of the same duration. Results Phantom experiments show that the proposed technique provides accurate quantification of T 1 and T 2 values over a wide‐range (T 1 : 260 ms to 1460 ms, T 2 : 40 ms to 200 ms). In vivo imaging shows that the proposed sequence quantifies T 1 and T 2 values similar to a saturation‐based T 1 mapping and a conventional breath‐hold T 2 mapping sequence, respectively. Conclusion The proposed sequence allows joint estimation of accurate and coregistered quantitative myocardial T 1 and T 2 maps in a single breath‐hold. Magn Reson Med 76:888–896, 2016. © 2015 Wiley Periodicals, Inc.