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Validation of a T 1 and T 2 * leakage correction method based on multiecho dynamic susceptibility contrast MRI using MION as a reference standard
Author(s) -
Stokes Ashley M.,
Semmineh Natenael,
Quarles C. Chad
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25906
Subject(s) - cerebral blood volume , leakage (economics) , cerebral blood flow , pharmacokinetics , dynamic contrast enhanced mri , nuclear medicine , computer science , chemistry , magnetic resonance imaging , medicine , radiology , pharmacology , cardiology , economics , macroeconomics
Purpose A combined biophysical‐ and pharmacokinetic‐based method is proposed to separate, quantify, and correct for both T 1 andT 2 *leakage effects using dual‐echo dynamic susceptibility contrast (DSC) acquisitions to provide more accurate hemodynamic measures, as validated by a reference intravascular contrast agent (CA). Theory and Methods Dual‐echo DSC‐MRI data were acquired in two rodent glioma models. The T 1 leakage effects were removed and also quantified to subsequently correct for the remainingT 2 *leakage effects. Pharmacokinetic, biophysical, and combined biophysical and pharmacokinetic models were used to obtain corrected cerebral blood volume (CBV) and cerebral blood flow (CBF), and these were compared with CBV and CBF from an intravascular CA. Results T 1 ‐corrected CBV was significantly overestimated compared with MION CBV, while T 1 + T 2 * ‐correction yielded CBV values closer to the reference values. The pharmacokinetic and simplified biophysical methods showed similar results and underestimated CBV in tumors exhibiting strongT 2 *leakage effects. The combined method was effective for correcting T 1 andT 2 *leakage effects across tumor types. Conclusion Correcting for both T 1 andT 2 *leakage effects yielded more accurate measures of CBV. The combined correction method yields more reliable CBV measures than either correction method alone, but for certain brain tumor types (e.g., gliomas), the simplified biophysical method may provide a robust and computationally efficient alternative. Magn Reson Med 76:613–625, 2016. © 2015 Wiley Periodicals, Inc.