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Balanced UTE‐SSFP for 19 F MR imaging of complex spectra
Author(s) -
Goette Matthew J.,
Keupp Jochen,
Rahmer Jürgen,
Lanza Gregory M.,
Wickline Samuel A.,
Caruthers Shelton D.
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25885
Subject(s) - steady state free precession imaging , pulse sequence , nuclear magnetic resonance , chemistry , precession , physics , nuclear medicine , magnetic resonance imaging , radiology , medicine , astronomy
Purpose A novel technique for highly sensitive detection of multiresonant fluorine imaging agents was designed and tested with the use of dual‐frequency 19 F/ 1 H ultrashort echo times (UTE) sampled with a balanced steady‐state free precession (SSFP) pulse sequence and three‐dimensional (3D) radial readout. Methods Feasibility of 3D radial balanced UTE‐SSFP imaging was demonstrated for a phantom comprising liquid perfluorooctyl bromide (PFOB). Sensitivity of the pulse sequence was measured and compared with other sequences imaging the PFOB (CF 2 ) 6 line group including UTE radial gradient‐echo (GRE) at α = 30°, as well as Cartesian GRE, balanced SSFP, and fast spin‐echo (FSE). The PFOB CF 3 peak was also sampled with FSE. Results The proposed balanced UTE‐SSFP technique exhibited a relative detection sensitivity of 51μ mol PFOB − 1min −1/2 (α = 30°), at least twice that of other sequence types with either 3D radial (UTE GRE: 20μ mol PFOB − 1min −1/2 ) or Cartesian k‐space filling (GRE: 12μ mol PFOB − 1min −1/2 ; FSE: 16μ mol PFOB − 1min −1/2 ; balanced SSFP: 23μ mol PFOB − 1min −1/2 ). In vivo imaging of angiogenesis‐targeted PFOB nanoparticles was demonstrated in a rabbit model of cancer on a clinical 3 Tesla scanner. Conclusion A new dual 19 F/ 1 H balanced UTE‐SSFP sequence manifests high SNR, with detection sensitivity more than two‐fold better than traditional techniques, and alleviates imaging problems caused by dephasing in complex spectra. Magn Reson Med 74:537–543, 2015. © 2014 Wiley Periodicals, Inc.