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Inflow‐vascular space occupancy (iVASO) reproducibility in the hippocampus and cortex at different blood water nulling times
Author(s) -
Rane Swati,
Talati Pratik,
Donahue Manus J.,
Heckers Stephan
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25836
Subject(s) - hippocampus , reproducibility , occupancy , cortex (anatomy) , neuroscience , biomedical engineering , space (punctuation) , medicine , nuclear magnetic resonance , biology , chemistry , computer science , physics , chromatography , ecology , operating system
Purpose Inflow‐vascular space occupancy (iVASO) measures arterial cerebral blood volume (aCBV) using accurate blood water nulling (inversion time [TI]) when arterial blood reaches the capillary, i.e., at the arterial arrival time. This work assessed the reproducibility of iVASO measurements in the hippocampus and cortex at multiple TIs. Methods The iVASO approach was implemented at multiple TIs in 10 healthy volunteers at 3 Tesla. aCBV values were measured at each TI in the left and right hippocampus, and the cortex. Reproducibility of aCBV measurements within scans (same day) and across sessions (different days) was assessed using the intraclass correlation coefficient (ICC). Results Overall hippocampal aCBV was significantly higher than cortical aCBV, likely due to higher gray matter volume. Hippocampal ICC values were high at short TIs (≤914 ms; intrascan values = 0.80–0.96, interscan values = 0.61–0.91). Cortically, high ICC values were observed at intermediate TIs of 914 (intra: 0.93, inter: 0.87) and 1034 ms (intra: 0.96, inter: 0.86). The ICC values were comparable to established contrast‐based CBV measures. Conclusion iVASO measurements are reproducible within and across sessions. TIs for iVASO measurements should be chosen carefully, taking into account heterogeneous arterial arrival times in different brain regions. Magn Reson Med 75:2379–2387, 2016. © 2015 Wiley Periodicals, Inc.