Premium
Relaxation along fictitious field, diffusion‐weighted imaging, and T 2 mapping of prostate cancer: Prediction of cancer aggressiveness
Author(s) -
Jambor Ivan,
Pesola Marko,
Merisaari Harri,
Taimen Pekka,
Boström Peter J.,
Liimatainen Timo,
Aronen Hannu J.
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25808
Subject(s) - prostate cancer , repeatability , spearman's rank correlation coefficient , intraclass correlation , nuclear medicine , prostatectomy , effective diffusion coefficient , receiver operating characteristic , kurtosis , medicine , diffusion mri , prostate , mathematics , nuclear magnetic resonance , magnetic resonance imaging , radiology , cancer , reproducibility , statistics , physics
Purpose To evaluate the performance of relaxation along a fictitious field (RAFF) relaxation time (T RAFF ), diffusion‐weighted imaging (DWI)‐derived parameters, and T 2 relaxation time values for prostate cancer (PCa) detection and characterization. Methods Fifty patients underwent 3T MR examination using surface array coils before prostatectomy. DWI was performed using 14 and 12 b values in the ranges of 0–500 s/mm 2 and 0–2000 s/mm 2 , respectively. Repeated MR examination was performed in 16 patients. T RAFF , DWI‐derived parameters (monoexponential, kurtosis, biexponential models), and T 2 values were measured and averaged over regions of interest placed in PCa and normal tissue. Repeatability of T RAFF and DWI‐derived parameters were assessed by coefficient of repeatability and intraclass correlation coefficient ICC(3,1). Areas under the receiver operating characteristic curve (AUCs) for PCa detection and Gleason score classification were estimated. The parameters were correlated with Gleason score groups using Spearman correlation coefficient (ρ). Results ICC(3,1) values for T RAFF were in the range of 0.82–0.92. T RAFF values had higher AUC values for Gleason score classification compared with DWI‐derived parameters and T 2 . The RAFF method demonstrated the highest ρ value (−0.65). Conclusion In a quantitative region of interest–based analysis, RAFF outperformed DWI (“low” and “high” b values) and T 2 mapping in the characterization of PCa. Magn Reson Med 75:2130–2140, 2016. © 2015 Wiley Periodicals, Inc.