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Second‐order motion‐compensated spin echo diffusion tensor imaging of the human heart
Author(s) -
Stoeck Christian T.,
von Deuster Constantin,
Genet Martin,
Atkinson David,
Kozerke Sebastian
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25784
Subject(s) - diffusion mri , systole , nuclear magnetic resonance , spin echo , diffusion , cardiac cycle , diastole , physics , magnetic resonance imaging , medicine , cardiology , radiology , blood pressure , thermodynamics
Purpose Myocardial microstructure has been challenging to probe in vivo. Spin echo–based diffusion‐weighted sequences allow for single‐shot acquisitions but are highly sensitive to cardiac motion. In this study, the use of second‐order motion‐compensated diffusion encoding was compared with first‐order motion‐compensated diffusion‐weighted imaging during systolic contraction of the heart. Methods First‐ and second‐order motion‐compensated diffusion encoding gradients were incorporated into a triggered single‐shot spin echo sequence. The effect of contractile motion on the apparent diffusion coefficients and tensor orientations was investigated in vivo from basal to apical level of the heart. Results Second‐order motion compensation was found to increase the range of systolic trigger delays from 30%–55% to 15%–77% peak systole at the apex and from 25%–50% to 15%–79% peak systole at the base. Diffusion tensor analysis yielded more physiological transmural distributions when using second‐order motion‐compensated diffusion tensor imaging. Conclusion Higher‐order motion‐compensated diffusion encoding decreases the sensitivity to cardiac motion, thereby enabling cardiac DTI over a wider range of time points during systolic contraction of the heart. Magn Reson Med 75:1669–1676, 2016. © 2015 Wiley Periodicals, Inc.