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13 C MRS of human brain at 7 T esla using [2‐ 13 C ]glucose infusion and low power broadband stochastic proton decoupling
Author(s) -
Li Shizhe,
An Li,
Yu Shao,
Ferraris Araneta Maria,
Johnson Christopher S.,
Wang Shumin,
Shen Jun
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25721
Subject(s) - decoupling (probability) , in vivo , amide , nuclear magnetic resonance , proton , physics , chemistry , nuclear overhauser effect , broadband , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , chromatography , nuclear physics , optics , engineering , biochemistry , microbiology and biotechnology , control engineering , biology
Purpose Carbon‐13 ( 13 C) MR spectroscopy (MRS) of the human brain at 7 Tesla (T) may pose patient safety issues due to high radiofrequency (RF) power deposition for proton decoupling. The purpose of present work is to study the feasibility of in vivo 13 C MRS of human brain at 7 T using broadband low RF power proton decoupling. Methods Carboxylic/amide 13 C MRS of human brain by broadband stochastic proton decoupling was demonstrated on a 7 T scanner. RF safety was evaluated using the finite‐difference time‐domain method. 13 C signal enhancement by nuclear Overhauser effect (NOE) and proton decoupling was evaluated in both phantoms and in vivo. Results At 7 T, the peak amplitude of carboxylic/amide 13 C signals was increased by a factor of greater than 4 due to the combined effects of NOE and proton decoupling. The 7 T 13 C MRS technique used decoupling power and average transmit power of less than 35 watts (W) and 3.6 W, respectively. Conclusion In vivo 13 C MRS studies of human brain can be performed at 7 T, well below the RF safety threshold, by detecting carboxylic/amide carbons with broadband stochastic proton decoupling. Magn Reson Med 75:954–961, 2016. © 2015 Wiley Periodicals, Inc.