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Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia
Author(s) -
Walvick Ronn P.,
Roche John P.,
Reno Austin L.,
Gounis Matthew J.,
Albert Mitchell S.
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25714
Subject(s) - medicine , lung , pulmonary artery , ischemia , pulmonary embolism , nuclear medicine , oxygen , magnetic resonance imaging , cardiology , radiology , chemistry , organic chemistry
Purpose In this study, a new model of pulmonary embolism in rats was developed and tested, to examine if hyperpolarized (HP) 3 He MR images can measure impairment of the exchange of oxygen from the airspaces to the blood during pulmonary embolism. Methods HP 3 He MRI was used to image six treatment‐group rats in which a branch of the pulmonary artery was embolized, and six control‐group rats. HP 3 He MR images were used to calculate the initial partial pressure of oxygen ( p O ) and the rate of oxygen depletion ( R ) in rat lungs. Results The p O was significantly higher in the ischemic lung than in the contralateral normal side, and p O was significantly higher in the ischemic lung than in both sides of the control lungs. Mean R in ischemic lungs was significantly lower than in the contralateral lungs, and mean R in ischemic lungs was also significantly lower than in both control lungs. Conclusion These results demonstrate that p O and R , as measured by the T 1 decay of HP 3 He, are sensitive to pulmonary ischemia in rats, confirming the findings in studies performed in large animal models of pulmonary ischemia. Magn Reson Med 75:2050–2054, 2016. © 2015 Wiley Periodicals, Inc.