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Quantitative and functional pulsed arterial spin labeling in the human brain at 9.4 t
Author(s) -
Bause Jonas,
Ehses Philipp,
Mirkes Christian,
Shajan G.,
Scheffler Klaus,
Pohmann Rolf
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25671
Subject(s) - voxel , nuclear magnetic resonance , arterial spin labeling , multislice , chemistry , perfusion , nuclear medicine , physics , computer science , medicine , artificial intelligence , cardiology
Purpose The feasibility of multislice pulsed arterial spin labeling (PASL) of the human brain at 9.4 T was investigated. To demonstrate the potential of arterial spin labeling (ASL) at this field strength, quantitative, functional, and high‐resolution (1.05 × 1.05 × 2 mm 3 ) ASL experiments were performed. Methods PASL was implemented using a numerically optimized adiabatic inversion pulse and presaturation scheme. Quantitative measurements were performed at 3 T and 9.4 T and evaluated on a voxel‐by‐voxel basis. In a functional experiment, activation maps obtained with a conventional blood‐oxygen‐level‐dependent (BOLD)‐weighted sequence were compared with a functional ASL (fASL) measurement. Results Quantitative measurements revealed a 23% lower perfusion in gray matter and 17% lower perfusion in white matter at 9.4 T compared with 3 T. Furthermore almost identical transit delays and bolus durations were found at both field strengths whereas the calculated voxel volume corrected signal‐to‐noise ratio was 1.9 times higher at 9.4 T. This result was confirmed by the high‐resolution experiment. The functional experiment yielded comparable activation maps for the fASL and BOLD measurements. Conclusion Although PASL at ultrahigh field strengths is limited by high specific absorption rate, functional and quantitative perfusion‐weighted images showing a high degree of detail can be obtained. Magn Reson Med 75:1054–1063, 2016. © 2015 Wiley Periodicals, Inc.