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Improved T 1 , contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two‐point dixon for dynamic contrast‐enhanced magnetic resonance imaging
Author(s) -
Le Yuan,
Dale Brian,
Akisik Fatih,
Koons Karen,
Lin Chen
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25639
Subject(s) - pharmacokinetics , gadolinium , magnetic resonance imaging , nuclear magnetic resonance , nuclear medicine , chemistry , medicine , physics , radiology , organic chemistry
Purpose To evaluate the impact of fat and fat‐suppression on the quantification of T 1 , gadolinium concentration, and pharmacokinetic parameters in DCE‐MRI. Methods T 1 values were measured in fat‐free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two‐point Dixon and were compared with reference values measured with inversion recovery–prepared turbo spin echo. Relaxivity of gadolinium‐benzyloxypropionictetraacetate (Gd‐BOPTA) was measured in emulsions of Gd‐BOPTA solution and fat using Dixon in‐phase and water‐only images. Liver T 1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in‐phase and water‐only images and were correlated with liver fat signal fraction. Results T 1 values measured using Dixon water‐only and non–fat‐suppressed images matched the reference values; while T 1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water‐only images were less affected by the fat than those measured in the in‐phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in‐phase and water‐only images were significant ( P < 0.05) for T 1 , K trans , and incremental area under the curve, but not Ve ( P = 0.1). Conclusion Dixon water‐only images provided more reliable estimation of T 1 , Gd, and pharmacokinetic parameters when fat was present. Magn Reson Med 75:1677–1684, 2016. © 2015 Wiley Periodicals, Inc.