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Reproducibility of phase rotation stimulated echo acquisition mode at 3T in schizophrenia: Emphasis on glutamine
Author(s) -
Bustillo Juan R.,
Rediske Nathan,
Jones Thomas,
Rowland Laura M.,
Abbott Christopher,
Wijtenburg S. Andrea
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25638
Subject(s) - reproducibility , nuclear medicine , intraclass correlation , nuclear magnetic resonance , phosphocreatine , glutamine , voxel , flip angle , medicine , chemistry , magnetic resonance imaging , physics , radiology , biochemistry , chromatography , amino acid , energy metabolism
Purpose To determine the reproducibility and reliability of glutamine (Gln), measured with a very short echo time phase rotation stimulated echo acquisition mode (VTE‐PR STEAM) sequence at 3T, in subjects with schizophrenia. Methods Seven subjects with schizophrenia were scanned twice with VTE‐PR STEAM in a Siemens 3T TIM Trio scanner with a 32‐channel head coil. Spectroscopic data were collected from two voxels in gray matter, one in the dorsal anterior cingulate and the other in the medial occipital cortex. Reproducibility was assessed using coefficients of variation (CVs) and reliability with standard error of measurement and intraclass correlations (ICCs). Phantoms containing increasing concentrations of Gln in a physiologic solution of other neurometabolites with overlapping resonances were scanned to assess the validity of spectral Gln measurement. Results Very good reliability and reproducibility for Gln in both regions of interest were supported by CVs of ≤10.0% and ICCs of ≥0.6, respectively. Phantom studies documented a robust correspondence between known Gln concentrations and VTE‐PR STEAM measurements of this metabolite (R 2 = 0.988). Conclusion The VTE‐PR STEAM approach at 3T permits the longitudinal assessment of Gln and other 1 H MR spectroscopy neurometabolites in a clinically plausible setting. Magn Reson Med 75:498–502, 2016. © 2015 Wiley Periodicals, Inc.