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Multisite evaluations of a T 2 ‐relaxation‐under‐spin‐tagging ( TRUST ) MRI technique to measure brain oxygenation
Author(s) -
Liu Peiying,
Dimitrov Ivan,
Andrews Trevor,
Crane David E.,
Dariotis Jacinda K.,
Desmond John,
Dumas Julie,
Gilbert Guillaume,
Kumar Anand,
Maclntosh Bradley J.,
Tucholka Alan,
Yang Shaolin,
Xiao Guanghua,
Lu Hanzhang
Publication year - 2016
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25627
Subject(s) - relaxation (psychology) , nuclear magnetic resonance , medicine , nuclear medicine , chemistry , physics
Purpose Venous oxygenation (Y v ) is an important index of brain physiology and may be indicative of brain diseases. A T 2 ‐relaxation‐under‐spin‐tagging (TRUST) MRI technique was recently developed to measure Y v . A multisite evaluation of this technique would be an important step toward broader availability and potential clinical utilizations of Y v measures. Methods TRUST MRI was performed on a total of 250 healthy subjects, 125 from the developer's site and 25 each from five other sites. All sites were equipped with a 3 Tesla (T) MRI of the same vendor. The estimated Y v and the standard error (SE) of the estimation ε Yv were compared across sites. Results The averaged Y v and ε Yv across six sites were 61.1% ± 1.4% and 1.3% ± 0.2%, respectively. Multivariate regression analysis showed that the estimated Y v was dependent on age ( P = 0.009) but not on performance site. In contrast, the SE of the Y v estimation was site‐dependent ( P = 0.024) but was less than 1.5%. Further analysis revealed that ε Yv was positively associated with the amount of subject motion ( P < 0.001) but negatively associated with blood signal intensity ( P < 0.001). Conclusion This work suggests that TRUST MRI can yield equivalent results of Y v estimation across different sites. Magn Reson Med 75:680–687, 2016. © 2015 Wiley Periodicals, Inc.