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Estimation of arterial arrival time and cerebral blood flow from QUASAR arterial spin labeling using stable spline
Author(s) -
Castellaro Marco,
Peruzzo Denis,
Mehndiratta Amit,
Pillonetto Gianluigi,
Petersen Esben Thade,
Golay Xavier,
Chappell Michael A.,
Bertoldo Alessandra
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25525
Subject(s) - deconvolution , arterial spin labeling , voxel , cerebral blood flow , perfusion , singular value decomposition , computer science , quasar , blood flow , impulse (physics) , mathematics , biomedical engineering , physics , nuclear magnetic resonance , nuclear medicine , artificial intelligence , algorithm , medicine , cardiology , astrophysics , quantum mechanics , galaxy
Purpose QUASAR arterial spin labeling (ASL) permits the application of deconvolution approaches for the absolute quantification of cerebral perfusion. Currently, oscillation index regularized singular value decomposition (oSVD) combined with edge‐detection (ED) is the most commonly used method. Its major drawbacks are nonphysiological oscillations in the impulse response function and underestimation of perfusion. The aim of this work is to introduce a novel method to overcome these limitations. Methods A system identification method, stable spline (SS), was extended to address ASL peculiarities such as the delay in arrival of the arterial blood in the tissue. The proposed framework was compared with oSVD + ED in both simulated and real data. SS was used to investigate the validity of using a voxel‐wise tissue T 1 value instead of using a single global value (of blood T 1 ). Results SS outperformed oSVD + ED in 79.9% of simulations. When applied to real data, SS exhibited a physiologically realistic range for perfusion and a higher mean value with respect to oSVD + ED (55.5 ± 9.5 SS, 34.9 ± 5.2 oSVD + ED mL/100 g/min). Conclusion SS can represent an alternative to oSVD + ED for the quantification of QUASAR ASL data. Analysis of the retrieved impulse response function revealed that using a voxel wise tissue T 1 might be suboptimal. Magn Reson Med 74:1758–1767, 2015. © 2014 Wiley Periodicals, Inc.