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Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3‐O‐Methyl‐D‐glucose
Author(s) -
Rivlin Michal,
Tsarfaty Ilan,
Navon Gil
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25467
Subject(s) - chemistry , nuclear magnetic resonance , nuclear medicine , in vivo , magnetization transfer , pulse (music) , magnetic resonance imaging , gradient echo , medicine , radiology , physics , microbiology and biotechnology , detector , biology , electrical engineering , engineering
Purpose To evaluate the feasibility to detect tumors and metastases by the chemical exchange saturation transfer (CEST) MRI technique using 3‐O‐Methyl‐D‐glucose (3OMG), a nonmetabolizable derivative of glucose that is taken up rapidly and preferentially by tumors and is entirely excreted by the kidneys. Methods In vivo CEST MRI experiments were performed on a Bruker 7 Tesla Biospec on implanted orthotopic mammary tumors of mice before and following i.p. injection of 3OMG. The CEST images were generated by a series of gradient‐echo images collected from a single 1 mm coronal slice after a 1.2 s presaturation pulse, applied at offsets of ±1.2 ppm from the water and at B 1 power of 2.5 µT. Results Following 3OMG (1.5 g/kg) i.p. injection, an enhanced CEST effect of approximately 20% was visualized at the tumor within a few minutes. The signal slowly declined reaching half of its maximum at approximately 80 min. Conclusion Due to the large CEST effect of 3OMG and its low toxicity 3OMG‐CEST may serve for the detection of tumors and metastases in the clinic. Magn Reson Med 72:1375–1380, 2014. © 2014 Wiley Periodicals, Inc.