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Optimized saturation pulse train for human first‐pass myocardial perfusion imaging at 7T
Author(s) -
Tao Yuehui,
Hess Aaron T.,
Keith Graeme A.,
Rodgers Christopher T.,
Liu Alexander,
Francis Jane M.,
Neubauer Stefan,
Robson Matthew D.
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25262
Subject(s) - imaging phantom , perfusion , saturation (graph theory) , magnetic resonance imaging , first pass , pulse (music) , biomedical engineering , myocardial perfusion imaging , pulse wave , perfusion scanning , nuclear magnetic resonance , computer science , materials science , nuclear medicine , medicine , mathematics , radiology , physics , telecommunications , arithmetic , combinatorics , detector , jitter
Purpose To investigate whether saturation using existing methods developed for 3T imaging is feasible for clinical perfusion imaging at 7T, and to propose a new design of saturation pulse train for first‐pass myocardial perfusion imaging at 7T. Methods The new design of saturation pulse train consists of four hyperbolic‐secant (HS8) radiofrequency pulses, whose peak amplitudes are optimized for a target range of static and transmit field variations and radiofrequency power deposition restrictions measured in the myocardium at 7T. The proposed method and existing methods were compared in simulation, phantom, and in vivo experiments. Results In healthy volunteer experiments without contrast agent, average saturation efficiency with the proposed method was 97.8%. This is superior to results from the three previously published methods at 86/95/90.8%. The first series of human first‐pass myocardial perfusion images at 7T have been successfully acquired with the proposed method. Conclusion Existing saturation methods developed for 3T imaging are not optimal for perfusion imaging at 7T. The proposed new design of saturation pulse train can saturate effectively, and with this method first‐pass myocardial perfusion imaging is feasible in humans at 7T. Magn Reson Med 73:1450–1456, 2015. © 2014 The Authors. Magnetic Resonance in Medicine Published by Wiley Periodicals, Inc. on behalf of International Society of Medicine in Resonance.