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Tracer kinetic modeling in myocardial perfusion quantification using MRI
Author(s) -
Schwab Felix,
Ingrisch Michael,
Marcus Roy,
Bamberg Fabian,
Hildebrandt Kristof,
Adrion Christine,
Gliemi Christopher,
Nikolaou Konstantin,
Reiser Maximilian,
Theisen Daniel
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25212
Subject(s) - perfusion , tracer , perfusion scanning , nuclear magnetic resonance , medicine , cardiology , physics , nuclear physics
Purpose To investigate and compare several quantification methods of myocardial perfusion measurements, paying special attention to the relation between the techniques and the required measurement duration. Methods Seven patients underwent contrast‐enhanced rest and stress cardiac perfusion measurements at 3T. Three slices were acquired in each patient and were divided into 16 segments, leading to 112 rest and stress data curves, which were analyzed using various tracer kinetic models as well as a model‐free deconvolution. Plasma flow, plasma volume, and myocardial perfusion reserve were analyzed for the complete acquisition as well as for the first pass data only. Results Deconvolution analysis yielded stable results for both rest and stress analysis, while Fermi and one compartment models agree well for first pass data (rest measurements only) and prolonged data acquisition (stress measurements only). More complex models do not yield satisfactory results for the short measurement times investigated in this study. Conclusions When performing MRI‐based quantification of myocardial perfusion, care must be taken that the method used is appropriate for the time frame under investigation. When a numerical deconvolution is used instead of tracer kinetic models, more stable results are obtained. Magn Reson Med 73:1206–1215, 2015. © 2014 Wiley Periodicals, Inc.