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Time‐resolved TOF MR angiography in mice using a prospective 3D radial double golden angle approach
Author(s) -
Trotier Aurelien J.,
Lefrançois William,
Ribot Emeline J.,
Thiaudiere Eric,
Franconi JeanMichel,
Miraux Sylvain
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25201
Subject(s) - nuclear magnetic resonance , angiography , physics , nuclear medicine , medicine , radiology
Purpose To develop an undersampled anatomical, three‐dimensional (3‐D) time‐resolved magnetic resonance angiography (MRA) method for small animals based on time‐of‐flight (TOF) effect and radial sampling. Methods Mouse carotid arteries and Circle of Willis images were acquired on a 7T scanner with an electrocardiogram (ECG)‐triggered sequence. Preliminary experiments were used to generate an approximately uniform distribution of radial projections with a first golden angle and to produce anatomical TOF images. A second golden angle ratio between consecutive projections of cine acquisitions was added to make it possible to use a temporal filter during reconstruction of time‐resolved angiography. A decreasing number of projections were tested, and their impact on signal‐to‐noise ratio (SNR) and spatial resolution was assessed. Results In anatomical MRA, the undersampled radial approach efficiently allows fast acquisition of mouse angiogram in 3D (22 sec). It was also only slightly sensitive to motion and flow artifacts. The time‐resolved sequence can be performed with only 2,500 projections per cine and a temporal resolution under 4 ms in a relatively short acquisition time (less than 5 min). Conclusion This technique simultaneously provided high 3D isotropic spatial resolution and excellent temporal resolution with a good SNR level, allowing blood flow to be visualized in a restricted acquisition time. Magn Reson Med 73:984–994, 2015. © 2014 Wiley Periodicals, Inc.