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Quantification of circumferential, longitudinal, and radial global fractional shortening using steady‐state free precession cines: A comparison with tissue‐tracking strain and application in fabry disease
Author(s) -
ChengBaron June,
Chow Kelvin,
Pagano Joseph J.,
Punithakumar Kumaradevan,
Paterson D. Ian,
Oudit Gavin Y.,
Thompson Richard B.
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25166
Subject(s) - strain (injury) , radial stress , in vivo , diastole , systole , ejection fraction , finite element method , biomedical engineering , cardiology , medicine , physics , heart failure , biology , blood pressure , microbiology and biotechnology , thermodynamics
Purpose Conventional calculation of myocardial strain requires tissue‐tracking. A surrogate for strain called global fractional shortening (GFS) is proposed based on changes in dimensions of endocardial and epicardial surfaces without tissue‐tracking. Methods Three‐dimensional endocardial and epicardial left ventricular surfaces traced at end‐diastole and end‐systole using conventional steady‐state free precession cine images were used to calculate GFS cc (circumferential), GFS ll (longitudinal), and GFS rr (radial) using fractional length changes in each direction over the heart surface. GFS values were validated using finite element models (FEM) and in vivo using tagging‐derived strains ( ε cc ,ε ll ,ε rr ) in patients with a wide range of ejection fraction (EF) and diagnosis (n = 32). GFS was also measured in 31 patients with Fabry disease and matched healthy controls. Results GFS values were within 3% of average FEM‐derived Lagrangian strains and had good agreement in vivo ( GFS cc = −14 ± 4%, ε cc = −14 ± 4%, R 2 = 0.85; GFS ll = −12 ± 4%, ε ll = −12 ± 4%, R 2 = 0.72; GFS rr = 46 ± 21%). ε rr could not be measured reliably from tagging. Compared with healthy controls with matched EF, patients with Fabry disease had significantly increased GFS cc (Endo) (−28 ± 3% versus −25 ± 2%), decreased GFS cc(Epi) (−10 ± 2% versus −11 ± 2%) and decreased GFS ll for all components. Conclusion GFS yields similar values to conventionally measured strains without requiring tissue‐tracking. Compared with controls, patients with Fabry disease have significant differences in several GFS components. Magn Reson Med 73:586–596, 2015. © 2014 Wiley Periodicals, Inc.