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Optimization of the reference region method for dual pharmacokinetic modeling using Gd‐DTPA/MRI and 18 F‐FDG/PET
Author(s) -
Poulin Éric,
Lebel Réjean,
Croteau Étienne,
Blanchette Marie,
Tremblay Luc,
Lecomte Roger,
Bentourkia M'hamed,
Lepage Martin
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25151
Subject(s) - nuclear medicine , gadolinium , positron emission tomography , pharmacokinetics , medicine , magnetic resonance imaging , radiology , chemistry , organic chemistry
Purpose The combination of MRI and positron emission tomography (PET) offers new possibilities for the development of novel methodologies. In pharmacokinetic image analysis, the blood concentration of the imaging compound as a function of time, [i.e., the arterial input function (AIF)] is required for MRI and PET. In this study, we tested whether an AIF extracted from a reference region (RR) in MRI can be used as a surrogate for the manually sampled 18 F‐FDG AIF for pharmacokinetic modeling. Methods An MRI contrast agent, gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) and a radiotracer, 18 F‐fluorodeoxyglucose ( 18 F‐FDG), were simultaneously injected in a F98 glioblastoma rat model. A correction to the RR AIF for Gd‐DTPA is proposed to adequately represent the manually sampled AIF. A previously published conversion method was applied to convert this AIF into a 18 F‐FDG AIF. Results The tumor metabolic rate of glucose (TMRGlc) calculated with the manually sampled 18 F‐FDG AIF, the 18 F‐FDG AIF converted from the RR AIF and the 18 F‐FDG AIF converted from the corrected RR AIF were found not statistically different ( P > 0.05). Conclusion An AIF derived from an RR in MRI can be accurately converted into a 18 F‐FDG AIF and used in PET pharmacokinetic modeling. Magn Reson Med 73:740–748, 2015. © 2014 Wiley Periodicals, Inc.