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Susceptibility‐based analysis of dynamic gadolinium bolus perfusion MRI
Author(s) -
Bonekamp David,
Barker Peter B.,
Leigh Richard,
Zijl Peter C.M.,
Li Xu
Publication year - 2015
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25144
Subject(s) - quantitative susceptibility mapping , perfusion , gadolinium , dynamic contrast enhanced mri , cerebral blood flow , perfusion scanning , nuclear medicine , magnetic resonance imaging , bolus (digestion) , blood flow , white matter , biomedical engineering , nuclear magnetic resonance , medicine , materials science , radiology , physics , cardiology , metallurgy
Purpose An algorithm is developed for the reconstruction of dynamic, gadolinium (Gd) bolus MR perfusion images of the human brain, based on quantitative susceptibility mapping (QSM). Methods The method is evaluated in five perfusion scans obtained from four different patients scanned at 3 Tesla, and compared with the conventional analysis based on changes in the transverse relaxation rate ΔR 2 * and to theoretical predictions. QSM images were referenced to ventricular cerebrospinal fluid (CSF) for each dynamic of the perfusion sequence. Results Images of cerebral blood flow and blood volume were successfully reconstructed from the QSM‐analysis, and were comparable to those reconstructed using ΔR 2 *. The magnitudes of the Gd‐associated susceptibility effects in gray and white matter were consistent with theoretical predictions. Conclusion QSM‐based analysis may have some theoretical advantages compared with ΔR 2 *, including a simpler relationship between signal change and Gd concentration. However, disadvantages are its much lower contrast‐to‐noise ratio, artifacts due to respiration and other effects, and more complicated reconstruction methods. More work is required to optimize data acquisition protocols for QSM‐based perfusion imaging. Magn Reson Med 73:544–554, 2015. © 2014 Wiley Periodicals, Inc.