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Analysis of proton‐density bias corrections based on T 1 measurement for robust quantification of water content in the brain at 3 Tesla
Author(s) -
Abbas Zaheer,
Gras Vincent,
Möllenhoff Klaus,
Keil Fabian,
OrosPeusquens AnaMaria,
Shah Nadim J.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25086
Subject(s) - content (measure theory) , proton , relaxation (psychology) , nuclear magnetic resonance , yield (engineering) , signal (programming language) , brain tissue , plane (geometry) , physics , analytical chemistry (journal) , materials science , nuclear medicine , biomedical engineering , statistics , computer science , mathematics , chemistry , medicine , thermodynamics , mathematical analysis , nuclear physics , chromatography , programming language , geometry
Purpose Estimating tissue water content using high field MRI, such as 3 Tesla (T), is challenging due to the difficulty in dissociating the radio frequency inhomogeneity pattern from the signal arising from tissue intrinsic proton density (PD) variations. To overcome this problem the longitudinal relaxation time T 1 can be combined with an initial guess of the PD to yield the desired PD bias correction. However, it is necessary to know whether T 1 effects, i.e., any effect contributing to T 1 while being independent of tissue hydration, influence the estimated correction. Methods Twenty‐five healthy subjects underwent a quantitative 3T MRI protocol enabling acquisition of 64 slices with 1 mm in‐plane resolution and 2 mm slice thickness in 14 min. Influence of T 1 effects on the estimated water content map is evaluated using a dedicated method including T 1 and T 2 * information and region of interest‐based water content values are compared with the literature. Results Our analysis indicates that the PD bias correction based on T 1 is largely insensitive to T 1 effects. Besides, water content results are in good agreement with literature values obtained at 1.5T. Conclusion This study demonstrates the applicability of a PD bias correction based on T 1 to yield tissue water content at 3T. Magn Reson Med 72:1735–1745, 2014. © 2014 Wiley Periodicals, Inc.